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KMID : 1161920140110020148
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Journal of Medicine and Life Science
2014 Volume.11 No. 2 p.148 ~ p.152
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The management of prostatic diseases according to testosterone replacement therapy
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Lee Jun-Hyup
Huh Jung-Sik
Kim Young-Joo
Park Kyung-Kgi
Kim Sung-Dae
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Abstract
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Late onset hypogonadism (LOH) is defined as a biochemical syndrome associated with advancing age and characterized by a deficiency in serum testosterone with or without decreased tissue sensitivity to testosterone. The precise role of testosterone in the aging process of men remains unclear, and there have been few controlled clinical studies in aging men to investigate the effects of testosterone replacement therapy on various organs and human functions known to deteriorate with age. The effect of testosterone replacement therapy on the prostate is very important in terms of its safety in aging men. We recommend a careful and individualized evaluation of present health problems combined with assessment of prostatic health (rectal examination, transrectal ultrasound, and prostate specific antigen(PSA) measurement) be undertaken before testosterone replacement is initiated. Perhaps the most controversial topic in the ongoing discussion of testosterone-replacement therapy is the issue of risks of prostatic diseases. Recent reports suggesting increased risks associated with hormone replacement in women have aroused concern that men receiving hormone replacement may also be vulnerable to increased health risks. However, no large-scale, long-term studies have yet been initiated to assess the benefits and risks of testosteronereplacement therapy in men, in part because of theoretical concern regarding the risks of therapy, especially possible stimulation of prostate cancer by testosterone. The purpose of this review is to discuss what is known and not known regarding the risks of testosterone replacement therapy and to provide recommendations for the monitoring of men receiving testosterone treatment.
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KEYWORD
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late-onset, hypogonadism, prostate, monitoring
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